Rabbit Anti-Human CD220

Rabbit Anti-Human CD220 (50 ug)

DS-PB-00416
+

Antigen Information

Protein Name & Synonyms:
CD220
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 0.1mg/ml
Preparation:
Antisera to CD220 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

Specificity

This product detects an epitope within in the internal domain of human CD220, also known as Insulin receptor (INRS). CD220 is a heterotetrameric membrane glycoprotein consisting of four disulfide linked subunits; two alpha subunits and two beta subunits. CD220 is a member of the tyrosine kinase family of receptors, and mediates the effects of insulin and IGF-I (insulin-like growth factor-I) through the activation of insulin receptor substrate (IRS) proteins and downstream effector cascades.

Activation of CD220 leads to a number of cellular effects, including glucose uptake, the regulation of cell proliferation and gene expression. These effects mostly occur in skeletal muscle, fat and the liver. Neuronal CD220 signalling has been shown to have an important role in energy homeostasis, reproduction and the development of neurodegenerative diseases.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to CD220 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide corresponding to human CD220 - conjugated to KLH.
Preservative:
0.09%Sodium Azide (NaN3)

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.