Rabbit Anti-Human CD271

Rabbit Anti-Human CD271 (0.1 mg)

$420.00
DS-PB-00434
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Antigen Information

Protein Name & Synonyms:
CD271
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to CD271 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human, Mouse

This product detects a band of approximately 75-80kDa in A-20 cell lysate.

Specificity

This product recognizes CD271, a transmembrane protein of 70-75kDa, otherwise known as Nerve Growth Factor Receptor (NGFR). It is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4.

CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination.

Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer's Disease, cerebral oedema and retinoblastoma.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to CD271 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Recombinant human CD271
Preservative:
0.02%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.