Rabbit Anti-Human CD283

Rabbit Anti-Human CD283 (0.1 mg)

DS-PB-00436
+

Antigen Information

Protein Name & Synonyms:
CD283
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human CD283 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.
Species Reactivity:
Human, Mouse

This product detects a band of approximately 103.8kDa in human Daudi cell lysates.

Specificity

This product recognizes human CD283, otherwise known as toll receptor 3, a 103.8kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells.

TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded (ds) viral RNA, including that of the Influenza A and West Nile virus.

This product has been shown as suitable for use in IHC on EL4 cytospins at 1ug/ml.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to human CD283 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.

Immunogen:
Synthetic peptide corresponding to a 15 amino acid sequence located near human CD283 carboxy-terminus.
Preservative:
0.02%Sodium Azide (NaN3)

No posts found

Write A Review
U.S. Non-U.S.

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.