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Antigen Information
Protein Name & Synonyms:
CD49d
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human CD49d were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human
Specificity
This product detects an epitope within the C-terminal region of human CD49d, a 150kD protein also known as integrin alpha 4 (ITGA4). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. CD49d associates with CD29 (ITGB1) and ITGB7, to form VLA-4 (very late antigen-4), and Ã❏4Ã❏7 integrin respectively.
VLA-4 is expressed on lymphocytes, monocytes, mast cells, macrophages, basophils and eosinophils, and has key roles in inflammation, cellular adhesion and cellular activation. Ã❏4Ã❏7 is expressed mainly on lymphocytes, and plays a key role in lymphocyte recruitment to sites of inflammation.
VLA-4 is expressed on lymphocytes, monocytes, mast cells, macrophages, basophils and eosinophils, and has key roles in inflammation, cellular adhesion and cellular activation. Ã❏4Ã❏7 is expressed mainly on lymphocytes, and plays a key role in lymphocyte recruitment to sites of inflammation.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to human CD49d were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Synthetic peptide: C-terminal domain of human CD49d, conjugated to KLH.
Preservative:
| 0.1% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
