Rabbit Anti-Human CD98 Light Chain (N-term)

Rabbit Anti-Human CD98 Light Chain (N-term) (50 ug)

$571.00
DS-PB-00447
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Antigen Information

Protein Name & Synonyms:
CD98
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to CD98 light chain were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

This product detects a band of approximately 50-55kDa in human liver cell lysates.

Specificity

This product detects an epitope within the N-terminal (NT) region of the CD98 light chain (CD98LC), also known as the 4F2 light chain, or LAT-1. CD98LC is a 40kD multi-pass membrane protein which forms a heterodimer with the CD98 heavy chain to allow transport of large branched chain, neutral amino acids into the cell. This transport system leads to the uptake of seven amino acids, including isoleucine, phenylalanine, and methionine.

The expression levels of CD98LC are upregulated in a wide spectrum of primary human cancers. Changes in amino acid transporter expression are thought to be an early change in oncogenesis, as they impart growth and survival advantages.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to CD98 light chain were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide: N-terminal region of CD98 light chain
Preservative:
0.1%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.