Rabbit Anti-Human Cyclin E

Rabbit Anti-Human Cyclin E

DS-PB-02445
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Antigen Information

Protein Name & Synonyms:
Cyclin E
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1/200, 1/500), Immunoprecipitation, Western Blotting
Preparation:
Antisera to cyclin E were raised by repeated immunisations of rabbits with highly purified antigen.
Species Reactivity:
Human, Mouse, Rat

This product detects a band of approximately 45kDa in from human, rat and mouse tissue.

Specificity

This product detects cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary.

Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication.

Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to cyclin E were raised by repeated immunisations of rabbits with highly purified antigen.

Immunogen:
Full length synthetic polypeptide corresponding to the human gene sequence of cyclin E.
Preservative:
0.01%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.