Rabbit Anti-Human DEDAF

Rabbit Anti-Human DEDAF

129-10238
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Antigen Information

Protein Name & Synonyms:
DEDAF
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
0.5 mg/ml
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat

This product detects a band of approximately 32kDa in human A549 cell lysates.

Specificity

This product recognizes human death effector domain associated factor (DEDAF), a 32kDa protein that associates with DED-containing proteins but does not itself contain a DED. DEDAF interacts with the death effector domains of FADD, DEDD and the proforms of caspase-8 and caspase-10. It augments the formation of complexes between CD95, FADD and caspase-8 at the cell membrane and enhances apoptosis.The protein was also independently identified as RING1 and YY1 binding protein (RYBP), which was implicated in the regulation of transcription.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to human DEDAF was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
A peptide corresponding to amino acids 215-228 of human DEDAF.
Preservative:
0.02% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.