Rabbit Anti-Human EGFR / ErbB1

Rabbit Anti-Human EGFR / ErbB1

$542.00
DS-PB-02596
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Antigen Information

Protein Name & Synonyms:
EGFR / ErbB1
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1/500, 1/5000), Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to EGF receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human, Mouse, Rat

This product detects a band of approximately 170kDa in A431 cell lysates.

Specificity

This product detects human epidermal growth factor receptor (EGFR), a 170kD transmembrane glycoprotein which is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut.

Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to EGF receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide corresponding to amino acids 1189-1199 of human EGF receptor protein.
Preservative:
0.01%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.