Rabbit Anti-Human ErbB4

Rabbit Anti-Human ErbB4

DS-PB-00720
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Antigen Information

Protein Name & Synonyms:
ErbB4
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to ErbB4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

Specificity

This product detects an epitope within the internal region of human ErbB4, a transmembrane protein which is a member of the epidermal growth factor receptor subfamily. ErbB4 is activated by a number of factors including neuregulins and betacellulin, which leads to the cleavage of a 120kD ectodomain fragment by TACE. In the cell, the remaining 80kD fragment of ErbB4 is internalised and cleaved by gamma-secretase. This fragment translocates to the nucleus and induces cell proliferation and differentiation.

ErbB4 is important in embryonic development, and mutations to its gene have been associated with cancer.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to ErbB4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide: Internal domain of human ErbB4.
Preservative:
0.09%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.