Protein Name & Synonyms:
Immunohistology - Paraffin
This product recognizes human Frizzled-7 (FZD7), a multi-pass membrane protein of 574 amino acids belonging to the G-protein coupled receptor FZ/Smo family.
FZD7 is a receptor for Wnt signaling proteins. FZD7 down regulates the functions of the tumor suppressor gene APC and thereby enhances beta catenin-mediated signals.
FZD7 is highly expressed adult skeletal muscle and fetal kidney. High expression is observed in the fetal lung, placenta, adult heart and brain tissues. It is specifically expressed in squamous cell oesophageal carcinomas.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Antisera to human FZD7 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
A synthetic peptide corresponding to the amino terminus of human FZD7 - conjugated to KLH.
0.09% Sodium Azide (NaN3)