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Antigen Information
Protein Name & Synonyms:
HSP90 alpha
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 1/500, 1/2500), Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human heat shock protein 90 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human
This product detects a band of approximately 90kDa.
Specificity
This product detects human heat shock protein 90 alpha (HSP90a), one of two HSP90 isoforms together with HSP90b. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesised proteins, and are also important in cellular processes such as hormone signalling and cell cycle control.
In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilised proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation.
Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.
In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilised proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation.
Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to human heat shock protein 90 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen:
Synthetic peptide corresponding to amino acids 289-300 of human heat shock protein 90 alpha.
Preservative:
| 0.09% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
