Rabbit Anti-Human IRAK4 (C-term.)

Rabbit Anti-Human IRAK4 (C-term.)

$420.00
129-10380
+

Antigen Information

Protein Name & Synonyms:
IRAK4
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Species Reactivity:
Human

This product detects a band of approximately 50kDa in HeLa cell lysates.

Specificity

This product detects an epitope within the C-terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 has a molecular weight of 50kD, and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization.

IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to IRAK4 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by chromatography.

Immunogen:
A peptide corresponding to amino acids at the carboxy terminus of human IRAK4.
Preservative:
0.02% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.