Rabbit Anti-Human LOX-1 (Extracell.)

Rabbit Anti-Human LOX-1 (Extracell.)

129-10418
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Antigen Information

Protein Name & Synonyms:
LOX-1
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: 1/100, 1/200), Immunofluorescence
Host Species:
Rabbit
Species Reactivity:
Human

Specificity

This product recognizes the extracellular (C-terminal) domain of human LOX-1, a receptor for oxidised low-density lipoproteins (LDL). This receptor mediates the recognition, internalisation and degradation of oxidised LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognizes the ligand. LOX-1 activation by oxidised LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by proatherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to human LOX-1 (extracellular domain) were raised by repeated immunisations of rabbits with highly purified antigen.

Immunogen:
Peptide corresponding to the C-terminal (extracellular) region of human LOX-1.
Preservative:
0.09% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.