Rabbit Anti-Human PACE4

Rabbit Anti-Human PACE4

DS-PB-01535
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Antigen Information

Protein Name & Synonyms:
PACE4
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to PACE4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

Specificity

This product detects an epitope within the internal region of human Paired basic amino acid cleaving system 4 (PACE4). PACE4 belongs to the subtilisin-like proprotein convertase family, and is a 100kD calcium dependent serine endoprotease located in the endoplasmic reticulum. It cleaves its substrates at their paired basic amino acid processing sites, converting them into their biologically active products. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor.

In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression. It is thought to have a similar role in humans.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to PACE4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide: internal domain of human PACE4.
Preservative:
0.09%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.