Rabbit Anti-Human PI3-K p110 delta (C-term.)

Rabbit Anti-Human PI3-K p110 delta (C-term.)

129-10531
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Antigen Information

Protein Name & Synonyms:
PI3-K p110 delta
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: , 1/3000), Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Immunogen Sequence:
SWKTKVNWLAHNVSKDNRQ
Species Reactivity:
Human

Specificity

This product specifically recognizes an epitope within the C-terminal (CT) region of human PI3-kinase p110 subunit delta (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta), a member of the PI3/PI4-kinase family of lipid kinases, implicated in the regulation of signal transduction during cell growth.

PI3-kinase is a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit, which itself is divided into isoforms p110alpha, p110beta, p110delta and p110gamma. Studies have shown that p110delta is predominantly restricted to leucocytes, exhibits a broad phosphoinositide lipid substrate specificity, and binds to Ras-GTP and p85.

This product is reported as suitable for use in immunocytochemistry.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to p110 delta (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide SWKTKVNWLAHNVSKDNRQ with added cysteine, corresponding to amino acids 1026-1044 within the C-terminal region of human PI3-Kinase p110 subunit delta.
Preservative:
0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.