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Antigen Information
Protein Name & Synonyms:
PKC zeta
Target Species:
- Human
Antibody Specifications
Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to protein kinase C zeta were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human
Specificity
This product detects an epitope within the N-terminal (NT) region of Protein kinase C zeta (PKCz), a 70kD member of the PKC family of serine/threonine kinases. PKCz is a member of the atypical PKC subfamily and has been widely implicated in the regulation of many cellular functions. PKCz activation is involved in the mitogen-activated protein kinase cascade, transcriptional factor NFkB activation, ribosomal S6-protein kinase signalling, and cell polarity.
PKC zeta may be a potential therapeutic target in asthma, and may have a putative role in other pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and lung cancer.
PKC zeta may be a potential therapeutic target in asthma, and may have a putative role in other pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and lung cancer.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to protein kinase C zeta were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Synthetic peptide: near the N-terminus of human protein kinase C zeta.
Preservative:
| 0.02% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
