Rabbit Anti-Human SHP2 (C-term)

Rabbit Anti-Human SHP2 (C-term)

$420.00
DS-PB-01808
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Antigen Information

Protein Name & Synonyms:
SHP2
Target Species:
  • Human

Antibody Specifications

Applications:
Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human SHP2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human, Expected cross reactivity from sequence similarity: mouse and rat

This product detects a band of approximately 68kDa in skeletal muscle tissue lysate.

Specificity

This product recognizes src homology 2 domain containing tyrosine phosphatase (SHP2), a 68 kDa member of the protein tyrosine phosphatase family. SHP2 acts downstream of growth factor receptors and cytoplasmic protein tyrosine kinases which transduce signals from cell surface to the nucleus. The recruitment and activation of SHP2 is mediated through the binding of CD172a to its ligand CD47.SHP2 regulates a variety of cellular processes. These include transcription, embryonic development, cell growth, cell migration, differentiation, mitotic cycle, hematopoiesis and oncogenic transformation. As a result, dysregulation of the SHP2 gene has been linked to LEOPARD, Noonan and Noonan-like syndrome as well as acute myeloid leukaemia. SHP2 is ubiquitously expressed, with highest levels found in heart, brain, and skeletal muscle.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to human SHP2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
14 amino acid peptide sequence near the carboxy terminus of human SHP2.
Preservative:
0.02%Sodium Azide

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.