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770-729-2992
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Product Specifications
Size:
50 µg
Protein Information
Protein Name & Synonyms:
SMAD3
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 1/2000, 1/20000), Immunohistology - Paraffin, Western Blotting
Concentration (lot specific):
IgG concentration 1.0mg/ml
Preparation:
Antiserum to human SMAD3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Human, Amphibia, Bovine, Chicken, Mouse, Pig, Rat, Zebrafish
Specificity
This product recognizes Mothers against decapentaplegic homolog 3 (SMAD3), a 50kDa transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase,
SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.
Studies have indicated that defects in SMAD3 may be a cause of colorectal cancer.
SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.
Studies have indicated that defects in SMAD3 may be a cause of colorectal cancer.
Storage/Stability
Prior to reconstitution store at +4 °C.
After reconstitution store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antiserum to human SMAD3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen:
Synthetic peptide corresponding to amino acids 417-425 of human SMAD3 protein.
Preservative:
0.01% Sodium Azide (NaN3)
Expiration:
12 months from the date of shipment when stored properly.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
