Rabbit Anti-Human SMIT-1 (C-term)

Rabbit Anti-Human SMIT-1 (C-term)

DS-PB-01822
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Antigen Information

Protein Name & Synonyms:
SMIT-1
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to SLC5A3 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

Specificity

This product detects an epitope within the C-terminal region of sodium-dependent myo-inositol cotransporter-1 (SLC5A3), also known as SMIT-1. SLC5A3 is a membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction. It is approximately 80kD in size.

Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to SLC5A3 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Synthetic peptide: C-terminal domain of human SLC5A3, conjugated to KLH.
Preservative:
0.09% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.