Protein Name & Synonyms:
Immunohistology - Paraffin, Western Blotting
Human, Mouse, Rat
This product detects a band of approximately 56kDa in Rat brain tissue lysate.
This product recognizes the Human Virus-induced-signalling-adaptor (VISA), also known as MAVS and KIAA1271, a protein of approximately 56.5kDa located on the mitochondrial membrane.
VISA is an important protein required for innate immune defence against viruses.
VISA acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothosized that VISA may protect cells from apoptosis.
VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, monocytes and epithelial cells, highest levels in tissues of the heart, skeletal muscle, liver, placenta and in peripheral blood leukocytes. Multiple isoforms of VISA have been identified.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Antisera to human VISA were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
A peptide corresponding to a 17 amino acid sequence from near the center of Human VISA.
0.02% Sodium Azide (NaN3)