Protein Name & Synonyms:
KCNJ3, GIRK1, KGA, KIR3.1, potassium voltage-gated channel subfamily J member 3
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Human, Mouse, Rat
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
WB 1:500 - 1:2000
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ3 (NP_002230.1).
Store at -20°. Avoid freeze / thaw cycles.