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Rabbit anti-KLHL3 Antibody

KLHL3 pAb

$460.00  
144-62902-200
+

Antigen Information

Accession Number:
  • Q9UH77
Gene ID:
  • 26249
Gene Symbols:
  • KLHL3
Protein Name & Synonyms:
KLHL3, PHA2D, kelch-like protein 3
Target Species:
  • Human

Antibody Specifications

Applications:
WB
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugation/Tag:
Unconjugated
Host Species:
Rabbit
Purity:
Affinity purification
Species Reactivity:
Human, Mouse
Isotype:
IgG

Background

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Dilutions

WB 1:500 - 1:2000

Format

Calculated MW
55kDa/61kDa/64kDa
Observed MW
75kDa

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human KLHL3 (NP_059111.2).

Modification

Unmodified

Storage

Store at -20°. Avoid freeze / thaw cycles.

Images

Western blot

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.

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