Rabbit Anti-Human p53DINP1

Rabbit Anti-Human p53DINP1

129-10510
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Antigen Information

Protein Name & Synonyms:
p53DINP1
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat

Specificity

This product recognizes p53DINP1 (p53-dependent damage-inducible nuclear protein 1). The protein promotes p53 phosphorylation on Ser46 in response to DNA double strand breaks, thereby inducing apoptosis. p53DINP1 is found in the nucleus and is ubiquitously expressed. Expression is dramatically reduced in pancreatic ductal adenocarcinomas early in the development of pancreatic cancer.

Two isoforms of the protein exists, a 27kDa alpha and an 18kDa beta form. This product detects a band of 27kDa in human lung tissue lysate. In human spleen, and mouse liver and kidney tissue a band is detected at 18kDa.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to p53DINP1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography.

Immunogen:
A peptide corresponding to 14 amino acids near the amino terminus of human p53DINP1.
Preservative:
0.02% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.