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Rabbit Anti-Human p63 (C-term.)

Rabbit Anti-Human p63 (C-term.)

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129-10512
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Antigen Information

Protein Name & Synonyms:
p63
Target Species:
  • Human

Antibody Specifications

Applications:
ELISA (dilution: , 1/1000), Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Immunogen Sequence:
C-NFDMDARRNKQQRIKEEGE
Species Reactivity:
Human, Mouse

This product detects a band of approximately 75kDa in mouse lung and human tumour cell line K562 (protein degredation is as expected).

Specificity

This product specifically recognizes an epitope within the C-terminal (CT) region of tumour protein p63, otherwise known as tumour protein p73-like (p73L), a widely expressed nuclear protein and homologue of tumour suppressor p53, which acts as a sequence-specific DNA binding transcriptional activator/repressor.

p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma.

This product is reported as suitable for use in immunocytochemistry.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antiserum to human p63 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Immunogen:
Synthetic peptide C-NFDMDARRNKQQRIKEEGE corresponding to amino acids 662-680 within the C-terminal region of p63.
Preservative:
0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.