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Antigen Information
Protein Name & Synonyms:
p63
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: , 1/1000), Western Blotting
Concentration:
1.0mg/ml
Host Species:
Rabbit
Immunogen Sequence:
C-NFDMDARRNKQQRIKEEGE
Species Reactivity:
Human, Mouse
This product detects a band of approximately 75kDa in mouse lung and human tumour cell line K562 (protein degredation is as expected).
Specificity
This product specifically recognizes an epitope within the C-terminal (CT) region of tumour protein p63, otherwise known as tumour protein p73-like (p73L), a widely expressed nuclear protein and homologue of tumour suppressor p53, which acts as a sequence-specific DNA binding transcriptional activator/repressor.
p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma.
This product is reported as suitable for use in immunocytochemistry.
p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma.
This product is reported as suitable for use in immunocytochemistry.
Storage/Stability
Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antiserum to human p63 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen:
Synthetic peptide C-NFDMDARRNKQQRIKEEGE corresponding to amino acids 662-680 within the C-terminal region of p63.
Preservative:
0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
0.1% Bovine Serum Albumin
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
