Protein Name & Synonyms:
PACS1, MRD17, SHMS, phosphofurin acidic cluster sorting protein 1
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
WB 1:1000 - 1:3000
Recombinant fusion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2).
Store at -20°. Avoid freeze / thaw cycles.