Rabbit Anti-PERK (N-term Q163)

Rabbit Anti-PERK (N-term Q163) Antibody, 400 µl

$420.00  
102-27481
+

Antigen Information

Accession Number:
  • Q9NZJ5
Gene ID:
  • 9451
Gene Symbols:
  • EIF2AK3
Protein Name & Synonyms:
Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK

Antibody Specifications

Applications:
WB, IHC-P
Clone:
RB15305
Host Species:
Rabbit
Species Reactivity:
H
Clonality:
Polyclonal
Isotype:
Rabbit Ig

Introduction

PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It likely serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction Expression of this Type I membrane protein is ubiquitous, with highest levels seen in secretory tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Other Information

NCBI Accession #
NP_004827.4
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Calculated Molecular Weight (Da)
125216
Antigen Source
Human

Images

WB (1:1000)

Western blot analysis of PERK Antibody (N-term Q163) (Cat. #102-27481) in 293 cell line lysates (35ug/lane). PERK (arrow) was detected using the purified Pab.

WB

Storage/Stability

2-8°C (short-term); -20°C (long-term)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.