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Antigen Information
Protein Name & Synonyms:
PPARG
Target Species:
- Human
Antibody Specifications
Applications:
ELISA (dilution: 1/8000, 1/32000)
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to PPAR gamma were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Species Reactivity:
Human
Specificity
This product detects human peroxisome proliferator-activated receptor γ (PPARG), a member of the nuclear hormone receptor subfamily of transcription factors. Upon activation, PPARG forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARG is principally involved in the cellular assimilation of lipids, with key roles in adipocyte differentiation and adipogenesis.
Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed.
PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed.
PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Antisera to PPAR gamma were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Immunogen:
Synthetic peptide corresponding to amino acids 255 - 268 of human PPAR gamma isoform 1.
Preservative:
| 0.01% | Sodium Azide (NaN3) |
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
