Rabbit Anti-Rat GluR1 (C-term)

Rabbit Anti-Rat GluR1 (C-term)

$667.00
DS-PB-00893
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Antigen Information

Protein Name & Synonyms:
GluR1
Target Species:
  • Rat

Antibody Specifications

Applications:
Immunohistology - Frozen, Immunoprecipitation, Western Blotting
Concentration:
Ig concentration 1 mg/ml
Immunogen Sequence:
S-H-S-S-G-M-P-L-G-A-T-G-L
Species Reactivity:
Rat, Hamster, Human, Monkey

Western blot analysis of rat brain shows a single band of approximately 110 kDa co-migrating with GluR1 expressed in transfected cells.

Immunohistology:
Paraformaldehyde or paraformaldehyde/glutaraldehyde are suitable. Cryostat and vibratome sections can be used with or without Triton X-100 treatment.

Specificity

This product recognizes the glutamate receptor 1 (also known as AMPA) which acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

This antibody linked to immobilized Protein A immunoprecipitates detergent-solubilized receptor from brain or transfected cells.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified Ig - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Synthetic peptide corresponding to the C terminal region of the native molecule conjugated to Bovine Serum Albumin.
Preservative:
0.09% Sodium Azide (NaN3
Amino Acid Sequence:
S-H-S-S-G-M-P-L-G-A-T-G-L

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.