Rabbit Anti-Rat GluR1 (pSer831)

Rabbit Anti-Rat GluR1 (pSer831)

DS-PB-00891
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Antigen Information

Protein Name & Synonyms:
GluR1 (pSer831)
Target Species:
  • Rat

Antibody Specifications

Applications:
Western Blotting
Preparation:
Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by sequential affinity chromatography on phospho- and dephosphopeptide affinity columns.
Species Reactivity:
Rat, Human, mouse

This product detects a band of approximately 100 kDa in rat brain lysates.

Specificity

This antibody is specific for rat glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 831.

GluR1, widely expressed throughout the nervous system, is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses.

Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.

Storage/Stability

Store at +4 °C or -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
10mM HEPES pH7.5
Format Type:
Purified

Preparation

Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by sequential affinity chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen:
Synthetic phosphopeptide corresponding to amino acid sequence within GluR1 which includes phosphorylated Ser831.
Preservative:
0.09%Sodium Azide
0.01%Bovine Serum Albumin
50%Glycerol

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.