Rabbit Anti-Rat GluR2

Rabbit Anti-Rat GluR2

$571.00
DS-PB-00896
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Antigen Information

Protein Name & Synonyms:
GluR2
Target Species:
  • Rat

Antibody Specifications

Applications:
Western Blotting
Preparation:
Antisera to rat GluR2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Species Reactivity:
Reacts with Rat and human based on sequence similarity Expected croos reactivity with mouse, chicken, monkey and zebrafish, based upon sequence similarity

This product detects a band of approximately 100 kDa in rat brain hippocampus cell lysates.

Specificity

This product is specific for glutamate receptor subunit 2 (GluR2), a component of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid) group of ionotropic glutamate receptors, which play a key role at excitatory synapses, including synaptic transmission, stabilisation and plasticity.

GluR2 is possibly the most important of the AMPA receptor subunits, responsible for AMPA receptor rectifying properties, control of ion flow and in particular the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2(R) form, containing a critical arginine residue (as opposed to a glutamine residue) in the Transmembrane region 2 (TM2) domain, thereby rendering native AMPA receptors impermeable to calcium.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
10mM Hepes pH7.5
Format Type:
Purified

Preparation

Antisera to rat GluR2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Immunogen:
Keyhole limpet hemocyanin conjugated synthetic peptide corresponding to an amino acid sequence within rat GluR2.
Preservative:
0.09%Sodium Azide
0.01%Bovine Serum Albumin
50%Glycerol

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.