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Antigen Information
Protein Name & Synonyms:
GRM1
Target Species:
- Rat
Antibody Specifications
Applications:
Immunohistology - Frozen, Western Blotting
Host Species:
Rabbit
Species Reactivity:
Rat
This product detects bands of approximately 125kDa (monomer) and 250kDa (dimer) on lysate from transfected HEK293 cells.
This antibody has also been reported to detect bands at approximately 120kDa (reduced) and 210kD (non-reduced), in protein extracts from adult rat cerebellum.
Specificity
This product recognizes rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3, 5-dihydroxyphenylglycine (DHPG).
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
10mM HEPES pH7.5, 150mM NaCl
Format Type:
Purified
Preparation
Antisera to metabotropic glutamate receptor 1a were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen:
Peptide corresponding to amino acids 1115-1130 from the C-terminal region of rat mGluR1a.
Preservative:
0.09% Sodium Azide (NaN3)
0.01% Bovine Serum Albumin
50% Glycerol
0.01% Bovine Serum Albumin
50% Glycerol
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
