Protein Name & Synonyms:
ELISA (dilution: 1/200, 1/2000), Immunohistology - Paraffin, Western Blotting
Human, Bovine, Mouse, Rat
This product recognizes the human Secreated Frizzled-Related Protein 1 (SFRP1), a multi functional secreted protein belonging to the sFRP family.
sFRPS function as modulators of Wnt signalling and have a role in the regulation of cell growth and differentiation in specific cell types. SFRP1 is widely expressed in human tissues (though absent from the lung, liver and peripheral blood leucocytes). Research demonstrates that SFRP1 has an anti-proliferative effect upon vascular cells, delaying the G1 phase and entry into S-phase in the cell cycle. It has also been demonstrated to that in kidney development, SFRP1 inhibits tubule formation and bud growth in metanephroi.
Research has also indicated that SFRP1 acts a tumour suppressor protein.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Antisera to Human SFRP1 were raised by repeated immunisation of Rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
A synthetic peptide corresponding to amino acids 43-54 of human SFRP1.
0.01% Sodium Azide (NaN3)