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Rabbit Anti-SIGLEC7 (D-siglec) (C-term H422)

Rabbit Anti-SIGLEC7 (D-siglec) (C-term H422) Antibody, 400 µl

$390.00  
102-22269
+

Antigen Information

Accession Number:
  • Q9NZQ1
  • Q9Y286
Gene ID:
  • 27036
Gene Symbols:
  • SIGLEC7
Protein Name & Synonyms:
Sialic acid-binding Ig-like lectin 7, Siglec-7, Adhesion inhibitory receptor molecule 1, AIRM-1, CDw328, D-siglec, QA79 membrane protein, p75, CD328, SIGLEC7, AIRM1

Antibody Specifications

Applications:
WB, IHC-P
Clone:
RB2715
Host Species:
Rabbit
Species Reactivity:
H
Clonality:
Polyclonal
Isotype:
Rabbit Ig

Introduction

SIGLECs are cell surface proteins of the Ig superfamily. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. A large subgroup of SIGLECs share high homology with SIGLEC3 (CD33) and are localized to 19q13.4. The cDNA for the SLG gene encodes 2 variants, SLG-long (SLGL) and SLG-short (SLGS). The 595-amino acid SLGL protein contains a signal peptide and 2 V-set N-terminal Ig-like domains. The 477-amino acid SLGS protein has a weak signal sequence and, like most SIGLEC3-like SIGLECs, has only 1 V-set N-terminal Ig-like domain. Both variants contain 2 C2-set N-terminal Ig-like domains, a transmembrane domain, and a cytoplasmic tail with a putative ITIM and a putative SLAM-like tyrosine-based motif. The conserved arginine residue thought to be essential for sialic acid binding in other SIGLECs is replaced by a glutamine in SLGS and by a cysteine in SLGL. RT-PCR analysis detected high expression of both variants in spleen and small intestine, and SLGS was highly expressed in adrenal gland and SLGL was highly expressed in bone marrow.

Other Information

NCBI Accession #
NP_001264130.1;NP_055200.1;NP_057627.2
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated Molecular Weight (Da)
51143
Antigen Source
Human

Images

WB (1:1000)

The anti-DSiglec C-term H422 Pab (Cat. #102-22269) is used in Western blot to detect DSiglec in Jurkat cell lysate.

WB

Storage/Stability

2-8°C (short-term); -20°C (long-term)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.