Rabbit anti-THPO Antibody

THPO Polyclonal Antibody

$200.00
144-01825-50
+

Antigen Information

Accession Number:
  • P40225
Gene ID:
  • 7066
Gene Symbols:
  • THPO
Protein Name & Synonyms:
THPO, MGDF, MKCSF, ML, MPLLG, THCYT1, TPO, thrombopoietin
Target Species:
  • Human

Antibody Specifications

Applications:
WB
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugation/Tag:
Unconjugated
Host Species:
Rabbit
Purity:
Affinity purification
Species Reactivity:
Human,Mouse
Clonality:
Polyclonal Antibodies
Isotype:
IgG

Background

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

Dilutions

WB 1:500 - 1:2000

Format

Calculated MW
33kDa/37kDa
Observed MW
32kDa

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-349 of human THPO (NP_001171068.1).

Modification

Unmodified

Storage

-20°C

Images

Western blot analysis of extracts of various cell lines, using THPO antibody (144-01825) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Western blot - THPO antibody (144-01825)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.