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770-729-2992
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Antigen Information
Accession Number:
- AAH14693
Protein Name & Synonyms:
TLR2
Antibody Specifications
Applications:
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~86 kDa TLR2 in Jurkat cell lysate. Reactivity to other species has not been tested. Blocking peptide is available separately.
Concentration:
0.5 mg/ml
Host Species:
Rabbit
Synonyms
TLR2 , Anti-TLR2 , CD282 , TIL4, Toll-like receptor 2
Description
The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Up-to-date, ten TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells. CD3+ T-cells and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulate TLR2, whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
Source
Immunogen
Synthetic peptide surrounding amino acid 753 of mouse TLR2
Purification
Affinity purified
Format
Physical Appearance
Colorless liquid
Formulation
100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Specificity
TLR2
Storage
-20 °C. The shelf life is 12 months.
No posts found
Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
