Rabbit Anti-TLR2 Antibody

Rabbit Anti-TLR2 Antibody, (100 ug)

$355.00  
168-10405
+

Antigen Information

Accession Number:
  • AAH14693
Protein Name & Synonyms:
TLR2

Antibody Specifications

Applications:
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~86 kDa TLR2 in Jurkat cell lysate. Reactivity to other species has not been tested. Blocking peptide is available separately.
Concentration:
0.5 mg/ml
Host Species:
Rabbit

Synonyms

TLR2 , Anti-TLR2 , CD282 , TIL4, Toll-like receptor 2

Description

The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Up-to-date, ten TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells. CD3+ T-cells and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulate TLR2, whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Source

Immunogen
Synthetic peptide surrounding amino acid 753 of mouse TLR2
Purification
Affinity purified

Format

Physical Appearance
Colorless liquid
Formulation
100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Specificity

TLR2

Storage

-20 °C. The shelf life is 12 months.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.