Rabbit Anti-YWHAH

Rabbit Anti-YWHAH

$420.00
DS-PB-00008
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Antigen Information

Protein Name & Synonyms:
YWHAH
Target Species:
  • Sheep

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Preparation:
Antisera to sheep 14-3-3 eta were raised by repeated immunisations of rabbit with highly purified antigen.
Species Reactivity:
Sheep, Bovine, Chicken, Human, Mouse, Rabbit, Rat

This product detects a band of approximately 30kDa in HEK293 cell lysates.

Specificity

This product recognizes 14-3-3 eta in all mammals. It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it❏'s different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.

14-3-3 eta is expressed principally in the brain although it is expressed at low levels in other tissues. The protein binds alpha-synuclein, forming part of lewy bodies in parkinsons disease and has been linked to early-onset schizophrenia. The eta isoform binds both gremlin 1, which is overexpressed in human cancers, and the DAL-1/Protein 4.1B tumour suppressor. Furthermore the glucocortcoid receptor is positively regulated by 14-3-3- eta.

This product may not react with recombinant proteins that are not N-acetylated.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Serum - liquid
Format Type:
Serum

Preparation

Antisera to sheep 14-3-3 eta were raised by repeated immunisations of rabbit with highly purified antigen.

Immunogen:
Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 eta.

Peptide sequence: Ac.GDREQLLQRARC
Preservative:
0.09%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.