Protein Name & Synonyms:
Immunohistology - Paraffin, Western Blotting
IgG concentration 1.0 mg/ml
This product recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin❏'s disease and Burkitt❏'s Lymphoma and is the causative agent in mononucleosis in adolescents.
EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases.
Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
This product specifically recognizes LMP2A and does not cross react with LMP2B.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Bacterial TrpE-LMP2A fusion protein
Spleen cells from immunised Lou/c rats were fused with cells of the P3X63.Ag8.653 myeloma cell line.