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Antigen Information
Protein Name & Synonyms:
AID
Target Species:
- Human
Antibody Specifications
Applications:
ELISA, Flow Cytometry, Immunohistology - Paraffin, Western Blotting
Concentration:
1.0 mg/ml
Host Species:
Rat
Species Reactivity:
Human
Specificity
This product specifically recognizes human AID (Activation-induced cytidine deaminase), a 24kDa RNA-editing enzyme essential for the initiation of immunoglobulin class switch recombination (CSR), somatic hypermutation (SHM) and gene conversion (GC).
Studies suggest that AID is selectively expressed by germinal center (GC) B cells and B cell-derived lymphomas, and that a deficiency in AID is responsible for the autosomal recessive form of the immunodeficient condition Hyper-IgM syndrome.
Studies suggest that AID is selectively expressed by germinal center (GC) B cells and B cell-derived lymphomas, and that a deficiency in AID is responsible for the autosomal recessive form of the immunodeficient condition Hyper-IgM syndrome.
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Synthetic peptide corresponding to amino acids 185-198 of human AID.
Preservative:
0.09% Sodium Azide (NaN3)
This product
Spleen cells from Long Evans rats were fused with cells of the P3X63-Ag8.653 myeloma cell line.
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Usage
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
