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Rat Anti-Human HLA ABC

Rat Anti-Human HLA ABC

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DS-MB-01537
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Antigen Information

Protein Name & Synonyms:
HLA ABC
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Frozen, Flow Cytometry, Functional Assays, Immunofluorescence, Immunoprecipitation
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Human

Specificity

The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells.

This product recognizes a monomorphic determinant on the human HLA Class I heavy chain. Epitope analysis has shown that this antibody binds in the alpha1 domain.

Recent studies have shown that this antibody may be able to induce apoptosis in activated but not resting T cells, see Genestier, L. et al. for details.

Storage/Stability

Store at +4 °C for one month or at -20 °C if preferred.

This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
PHA activated human peripheral blood lymphocytes.
Preservative:
0.09%Sodium Azide
This product
Spleen cells from immunised DA rats were fused with cells of the rat Y3 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.