Rat anti-Human/Monkey/Cow/Pig/Mouse/Fish Perlecan Antibody (HSPG)

Rat anti-Human/Monkey/Cow/Pig/Mouse/Fish Perlecan Antibody (HSPG)

$560.00  
188-10451-2
+

Antigen Information

Accession Number:
  • P98160
Gene ID:
  • 3339
Gene Symbols:
  • HSPG2
Protein Name & Synonyms:
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin, LG3 peptide]
Target Species:
  • Bovine (cow)
  • Fish
  • Human
  • Mouse
  • Non-human Primates
  • Porcine (pig)

Antibody Specifications

Applications:
Flow Cytometry: 0.5-1ug/million cells in 0.1ml
Immunofluorescence: 0.5-1ug/ml
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Concentration:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Domain/Region/Terminus:
Basement membrane
Host Species:
Rat
Preparation:
A murine EHS laminin preparation was used as the immunogen for the Perlecan antibody.
Purity:
Protein G affinity chromatography
Species Reactivity:
Human, Monkey, Cow, Pig, Mouse and Fish. Other species not tested.
Isotype:
Rat IgG2a, kappa

Description

This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Storage

Store the Perlecan antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.

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