Rat Anti-Mouse beta-Glucan Receptor [+RPE]

Rat Anti-Mouse beta-Glucan Receptor [+RPE]
CODE:  DS-MB-03705

Antigen Information

Protein Name & Synonyms:
beta-Glucan Receptor
Target Species:
  • Mouse

Antibody Specifications

Applications:
Flow Cytometry
Reconstitution:
Reconstitute with 1 ml distilled water
Species Reactivity:
Mouse

Specificity

This product recognizes murine beta-glucan receptor, also known as Dectin-1.Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.

As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens.

Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.

Storage/Stability

Store at +4 °C.

DO NOT FREEZE

This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 1 ml distilled water

Preparation

Immunogen:
Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1
Preservative:
0.09%Sodium Azide
1%Bovine Serum Albumin
5%Sucrose
This product
Spleen cells from immunised Fischer rats were fused with cells of the rat Y3 myeloma cell line