Rat Anti-Mouse CD253

Rat Anti-Mouse CD253 (0.1 mg)

129-10124
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Antigen Information

Protein Name & Synonyms:
CD253
Target Species:
  • Mouse

Antibody Specifications

Applications:
Flow Cytometry
Concentration:
0.5mg/ml
Host Species:
Rat
Species Reactivity:
Mouse

Specificity

This product recognizes mouse CD253, also known as TNF-related apoptosis-inducing ligand or TRAIL, a member of the tumour necrosis factor ligand superfamily. When bound to the death receptors DR4 and DR5 caspase-8-dependent apoptosis is induced. However, CD253 might also be bound by the decoy receptor DcR1 which cannot induce apoptosis, and DcR2 which activates NF-kappa-B.

This antibody has been reported to block NK cell cytotoxicity in vitro.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Mouse CD253-transfected 2PK-3 cells
Preservative:
0.09% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.