Rat Anti-Mouse CD254

Rat Anti-Mouse CD254 (0.25 mg)

129-10125
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Antigen Information

Protein Name & Synonyms:
CD254
Target Species:
  • Mouse

Antibody Specifications

Applications:
Immunohistology - Frozen, Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blotting
Concentration:
0.5mg/ml
Host Species:
Rat
Species Reactivity:
Mouse

Specificity

This product recognizes CD254, otherwise known as Receptor activator of nuclear factor kappa B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE), a member of the tumour necrosis factor ligand superfamily. CD254 is a cytokine that binds osteoprotegerin or RANK and plays an important role in bone metabolism, where it acts as an osteoclast differentiation and activation factor. Overproduction of CD254 is implicated in a range of degenerative bone diseases.

It is also expressed by T helper cells and augments the ability of dendritic cells to stimulate naive T cell proliferation. It may play a role in regulating interactions between T cells and dendritic cells and in the regulation of T cell-dependent immune responses.

This product blocks ligand binding.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Preservative:
0.09% Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.