Protein Name & Synonyms:
IgG concentration 1.0 mg/ml
This product recognizes mouse CD279, a 55kD cell surface protein which is a member of the CD28/CTLA-4 family, otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes.
Studies suggest that CD279, an immunoinhibitory receptor, plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family, B7-H1 (PD-L1) and B7-DC (PD-L2), have been identified as the ligands for CD279.
Antibodies produced by This product do not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells.
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
PD-1 transferred BHK cells
Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3U1 myeloma cell line.