Protein Name & Synonyms:
Immunohistology - Frozen, Flow Cytometry, Immunofluorescence
IgG concentration 1.0 mg/ml
This antibody recognizes murine CD301, a 38 kD cell surface protein that is otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR).
In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. This antibody also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated.
This antibody is reported to block the function of mouse CD301. The antibody binds both MGL1 and MGL2 homologues.
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
If stored in this manner, this product is stable for 18 months after receipt.
Purified IgG - liquid
Phosphate buffered saline
Balb/c macrophage precursor cell hybrids
Cells from immunised rats were fused with cells of the rat Y3-Ag1.2.3 myeloma cell line.