Rat Anti-Mouse CD98

This product recognizes murine CD98 (also known as 4F2 and SLC3A2), a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.

CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Studies suggest that overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis.