Rat Anti-Mouse CDw199 [+RPE]

Rat Anti-Mouse CDw199 [+RPE] (100 TESTS)

129-10186
+

Antigen Information

Protein Name & Synonyms:
CDw199
Target Species:
  • Mouse

Antibody Specifications

Applications:
Flow Cytometry
Host Species:
Rat
Reconstitution:
Reconstitute with 1.0ml distilled water
Species Reactivity:
Mouse

Specificity

This product detects mouse chemokine receptor 9 (CCR9), also known as CDw199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9.

CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.

This product blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.

Storage/Stability

Store at +4 °C. DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light.
Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Formulation:
Phosphate buffered saline
Reconstitution:
Reconstitute with 1.0ml distilled water

Preparation

Immunogen:
25 amino acids from the amino terminal of murine CCR9, coupled to KLH.
Preservative:
0.09%Sodium Azide (NaN3)
1%Bovine Serum Albumin
5%Sucrose
This product
Spleen cells from immunised Lewis rat were fused with cells of the X63-Ag8.653 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.