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Rat Anti-Mouse CDw199

Rat Anti-Mouse CDw199 (0.1 mg)

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129-10184
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Antigen Information

Protein Name & Synonyms:
CDw199
Target Species:
  • Mouse

Antibody Specifications

Applications:
Flow Cytometry
Concentration:
1.0mg/ml
Host Species:
Rat
Species Reactivity:
Mouse

Specificity

This product detects mouse chemokine receptor 9 (CCR9), also known as CDw199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9.

CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.

This antibody blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
25 amino acids from the amino terminal of murine CCR9, coupled to KLH.
Preservative:
0.09%Sodium Azide (NaN3)
This product
Spleen cells from immunised Lewis rat were fused with cells of the X63-Ag8.653 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.