Rat Anti-Mouse ER-HR3

Rat Anti-Mouse ER-HR3

DS-MB-03897
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Antigen Information

Protein Name & Synonyms:
ER-HR3
Target Species:
  • Mouse

Antibody Specifications

Applications:
Immunohistology - Frozen, Flow Cytometry
Concentration:
IgG concentration 1.0 mg/ml
Species Reactivity:
Mouse

Specificity

This antibody recognizes the murine antigen ER-HR3. ER-HR3 is a cell surface antigen which is expressed by Langerhans cells in epithelium, a subset of mature macrophages and dendritic cells that are located predominantly in hematopoietic and lymphoid organs. Initial studies of ER-HR3 demonstrated expression on peripheral blood monocytes but recent studies suggest that expression is actually very low.

During fetal development, ER-HR3 positive cells are localised to hemapoietic islands and are often associated with erythroid progenitor cells. The functions of the ER-HR3 antigen have not been established but reports suggest that the antigen may be involved in adult erythropoiesis and in the regulation of the immune response.

This product does not inhibit T cell proliferation in antigen-specific T-cell proliferation studies.

This product recognizes two proteins of approximately 69kD and 55kD under non-reducing conditions.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Immunogen:
Adherent F1 (CBAxBL) bone marrow stormal cells.
Preservative:
0.09%Sodium Azide
This product
Cells from immunised rats were fused with cells of the mouse P3 - X63 - Ag8.563 myeloma cell line.

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.