5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is anenzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including theliver, brain, and skeletal muscle. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. 5'-AMP-activated protein kinase catalytic subunit alpha-1(AMPKa1) is the catalytic subunit of AMPK. AMPKa1/2-PT is the phosphorylated form of AMPKa1.

The antibody is stable for at least 1 year from the date of receipt when stored at -20^°C to -70^°C. Reconstituted antibody can also be aliquotted and stored at 4^°C for 1 month or at -20^°C to -70^°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.